Pharm

Temazepam

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Temazepam, Restoril

  • See Also
  1. Benzodiazepine
  • Class
  1. Medium Acting Benzodiazepine
  • Indications
  1. Insomnia with frequent awakening
    1. Short-term use only (7 to 10 days)
  1. Start 15 mg orally taken 1 to 2 hours before bedtime (7.5 mg in elderly or debilitated)
  2. Maximum Dose: 30 mg at bedtime (15 mg in elderly)
  • Pharmacokinetics
  1. Onset: 30-60 minutes
  2. Serum Peak Level: 2-3 hours after oral dose
  3. Duration: 6-8 hours
  4. Half-Life: 8-15 hours
    1. May be as long as 25 hours in some patients due to potentially active metabolites
  5. Metabolism to Glucuronidation
  1. Valium = Dose x1.0
  2. Phenobarbital = Dose x3.0
  • Advantages
  1. Less daytime sedation or accumulation
  • Disadvantages
  1. More risk of rebound Insomnia
  • Resources
  1. Temazepam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a3f06243-fa03-4cbd-951a-144ec43dcdfd
  • References
  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia