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Oxazepam

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Oxazepam, Serax

  • See Also
  1. Benzodiazepine
  • Indications
  1. Anxiety Disorder
  2. Anxiety with comorbid Major Depression
  3. Alcohol Withdrawal
  • Class
  1. Short acting Benzodiazepine
  • Pharmacokinetics
  1. Half Life: 8 to 15 hours
  2. Metabolism via Glucuronidation to inactive metabolites
  1. Anxiety Disorder
    1. Elderly: 10 mg orally 3 times daily (and may advance to 15 mg orally 3 to 4 times daily)
    2. Moderate: 10 to 15 mg orally 3 to 4 times daily
    3. Severe: 15 to 30 mg orally 3 to 4 times daily
    4. Maximum Daily Dose: 120 mg/day
  2. Acute Alcohol Withdrawal
    1. Give 15 to 30 mg orally three to four times daily
  1. Valium = Dose x1.0
  2. Phenobarbital = Dose x3.0
  • Safety
  1. Pregnancy Category D
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance
  • Resources
  1. Oxazepam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a0d5a4c1-ec79-42e6-8e8f-ae4d144edb43
  • References
  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia