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Isocarboxazid

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Isocarboxazid, Marplan

  • See Also
  1. MAO Inhibitor
  2. Antidepressant
  • Precautions
  1. See MAO Inhibitors
  2. Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
  3. MAO Inhibitors are not first-line agents for Mood Disorders
  • Indications
  1. Refractory Major Depression
  • Background
  1. Isocarboxazid (Marplan) is no longer manufactured in U.S.
  • Mechanism
  1. See MAO Inhibitor
  2. Isocarboxazid is a hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
  • Dosing
  1. Start 10 mg orally twice daily
  2. May increase the daily dose by 10 mg every 2 to 4 days to 40 mg in the first 1-2 weeks (in divided doses)
  3. Maximum: 60 mg per day (in divided doses)
  • Adverse Effects
  1. See MAO Inhibitor
  • Drug Interactions
  1. See MAO Inhibitors
  2. Hepatic metabolism
  • Safety
  1. Unknown safety in pregnancy and Lactation
  • Resources
  1. Isocarboxazid (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac387aa0-3f04-4865-a913-db6ed6f4fdc5
  • References
  1. (2023) Med Lett Drugs Ther 62(1592): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia