Pharm

Clomipramine

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Clomipramine, Anafranil

  • See Also
  1. Tricyclic Antidepressant
  2. Obsessive Compulsive Disorder
  • Indications
  1. Obsessive Compulsive Disorder
  • Mechanism
  1. See Tricyclic Antidepressant
  2. Very strong Serotonin uptake blockade
  3. Primarily blocks Serotonin uptake
  • Safety
  1. Pregnancy Category C
  2. Safe in Lactation
  • Dosing
  1. Adult
    1. Start 25 mg orally at bedtime
    2. Titrate to 100 mg/day in divided doses with meals over 2 to 4 week period
    3. Max: 250 mg/day
      1. May consolidate divided doses into one nightly dose after titration
  2. Child (over age 10 years)
    1. Start 25 mg orally at bedtime
    2. Titrate to 3 mg/kg/day (up to 100 mg/day) in divided doses with meals over 2 to 4 week period
    3. Max: 3 mg/kg/day (up to 200 mg/day)
      1. May consolidate divided doses into one nightly dose after titration
  • Adverse Effects
  1. See Tricyclic Antidepressant
  2. Very sedating
  • Pharmacokinetics
  1. Half-Life: 20-35 hours
  • Resources
  1. Clomipramine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4074b555-7635-41a9-809d-fae3b3610059
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 38-9
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia