Analgesic

Piroxicam

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Piroxicam, Feldene, Fexicam

  • See Also
  1. NSAID
  2. Meloxicam
  • Indications
  1. See NSAID
  2. FDA approved indications in Adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
  • Contraindications
  1. See NSAID
  • Mechanism
  1. See NSAID
  2. NSAID in the Oxicam Class
  3. Piroxicam has a long half life and may be dosed daily
  4. Additional mechanisms beyond inhibition of Prostaglandin synthesis
    1. Inhibits Neutrophil aggregation
    2. Inhibits Lysosome enzyme release
  • Medications
  1. Piroxicam capsules 10 mg, 20 mg
  • Dosing
  • Adults
  1. Arthritis (OA, RA): 20 mg orally daily (or divided twice daily)
  • Adverse Effects
  1. See NSAID
  • Safety
  1. See NSAID
  2. Considered safe in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)
  • Resources
  1. Piroxicam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a6335245-7e04-46b9-a505-f47647781e19