• See Also
  1. See NSAID
  • Indications
  1. See NSAID
  2. FDA Approved Indications in Adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
  • Contraindications
  1. See NSAID
  • Mechanism
  1. See NSAID
  2. Nabumetone is a prodrug
    1. Undergoes hepatic catalysis, converting it to the active (6-methoxy-2-naphthylacetic acid)
    2. 6MNA is partially COX2-selective
  • Medications
  1. Nabumetone tablets 500 mg, 750 mg, 1000 mg
  • Dosing
  • Adults
  1. Arthritis (OA, RA)
    1. Start: 1000 mg orally daily (or divided twice daily)
    2. May titrate to 1500 to 2000 mg orally daily (or divided twice daily)
  • Adverse Effects
  1. See NSAID
  • Safety
  1. See NSAID
  2. Avoid in Lactation
  3. Avoid NSAIDs in pregnancy outside the first part of the second trimester (13 to 20 weeks)
    1. Teratogenic in first trimester
    2. Risk of premature ductus arteriosus closure in the fetus in third trimester
    3. Most NSAIDs carry a legacy system Pregnancy Category B or C designation (aside from third trimester)
      1. However, many obstetricians avoid NSAIDs entirely in pregnancy (even in second trimester)
  • Resources
  1. Nabumetone
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ef7c3da8-797f-4ea9-8999-53509785a0f7