Tremor
Atypical Pakinsonism
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Atypical Pakinsonism
, Atypical Parkinson's Disease, Atypical Parkinson Disease
See Also
Parkinson's Disease
Course
Rapidly progressive or early
Dementia
Rapidly progressive course
Signs
Prominent features
Upper Motor Neuron
signs
Axial rigidity is greater than extremity rigidity
Cerebellar signs (dysmetria,
Ataxia
) with impaired gait
Impaired speech
Urinary Incontinence
Early symptomatic
Postural Hypotension
Distinguishing features
Resting
Tremor
absent
Refractory to
Carbidopa/Levodopa
Signs
Progressive Supranuclear palsy (Supranuclear
Gaze Palsy
)
Olfaction is normal
Vertical
Gaze Paralysis
and postural instability
Difficulty reading
Loss of Down gaze
References
Ahlskog (2011) Mayo Internal Medicine Review Lecture
Schim (2001) CMEA Medicine Lecture, San Diego
Clarke (2003) Clin Evid 10:1582-98 [PubMed]
Clarke (2004) Lancet Neurol 3:466-74 [PubMed]
Gazewood (2013) Am Fam Physician 87(4): 267-73 [PubMed]
Nutt (2005) N Engl J Med 353:1021-7 [PubMed]
Olanow (2001) Neurology 56:S1-88 [PubMed]
Rao (2006) Am Fam Physician 74:2046-56 [PubMed]
Young (1999) Am Fam Physician 59(8):2155-67 [PubMed]
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