Pharm

Muscarinic Agonist

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Muscarinic Agonist, Pilocarpine, Salagen, Cevimeline, Evoxac

  • Indications
  1. Sjogren's Syndrome Dry Eyes (and possibly Dry Mouth) refractory to general measures
  • Contraindications
  1. Angle closure Glaucoma
  2. Uncontrolled Asthma
  • Adverse effects
  1. Diaphoresis
  2. Decreased night Vision
  3. Nonselective agents (Pilocarpine) may have cardiopulmonary effects
  • Medications
  1. Pilocarpine (Salagen)
    1. Nonselective (may have cardiac or lung effects)
    2. Dose: 5 mg orally twice daily
  2. Cevimeline (Evoxac)
    1. Selective for exocrine glands
    2. Dose: 30 mg orally three times daily