Pharm

Dalfampridine

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Dalfampridine, 4-Aminopyridine, Pymadine, Fampridine, Dalfampridine XR, Ampyra

  • See Also
  1. Multiple Sclerosis
  • Indications
  1. Multiple Sclerosis related ambulatory dysfunction
  • Contraindications
  1. Seizure Disorder
  2. Renal Dysfunction (increases Dalfampridine drug levels)
    1. Dalfampridine is contraindicated with GFR <50 ml/min
    2. Seizure risk increased for GFR 50 to 80 ml/min
  • Mechanism
  1. Primarily a Potassium Channel Blocker
  2. Also blocks Calcium channels
  3. May improve ambulation in Multiple Sclerosis
  • Medications
  1. Dalfampridine XR 10 mg tablets
  • Dosing
  1. Adults: Dalfampridine XR 10 mg orally twice daily
  • Adverse Effects
  1. Seizures
    1. Increased risk with renal dysfunction (GFR 50 to 80 ml/min)
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Resources
  1. Dalfampridine XR (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=550eb76a-e4a6-4fa1-ad65-c0fd8b0ce783