- Multiple Sclerosis related ambulatory dysfunction
- Seizure Disorder
- Renal Dysfunction (increases Dalfampridine drug levels)
- Dalfampridine is contraindicated with GFR <50 ml/min
- Seizure risk increased for GFR 50 to 80 ml/min
- Primarily a Potassium Channel Blocker
- Also blocks Calcium channels
- May improve ambulation in Multiple Sclerosis
- Dalfampridine XR 10 mg tablets
- Adults: Dalfampridine XR 10 mg orally twice daily
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Seizures
- Increased risk with renal dysfunction (GFR 50 to 80 ml/min)
- Pregnancy Category C
- Unknown safety in Lactation
- Dalfampridine XR (DailyMed)