- Conditions
- Community Acquired Pneumonia
- Refractory acute Bacterial Sinusitis (third line agent)
- Activity Spectrum
- Gram Negative Rod coverage (see other Fluoroquinolones)
- Atypical Bacteria
- Moderate Gram Positive activity
- See Fluoroquinolone
-
Levofloxacin (Levaquin)
- Adult Dose 250 to 750 mg orally or IV daily
- QT Prolongation with Levofloxacin (Levaquin)
- Three fold increased risk of Sudden Cardiac Death while on Levofloxacin
- This appears to be a class effect with most Fluoroquinolones except Ciprofloxacin
- Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]
-
Moxifloxacin (Avelox)
- Low urine concentrations (avoid in UTI)
- No Pseudomonas coverage
- Highest risk Quinolone for QT Prolongation
- Sparfloxacin (Zagam)
- Associated with higher rates of Photosensitivity Reactions and was withdrawn from U.S. market in 2001
- Low urine concentrations (avoid in UTI)
- Gatifloxacin (Tequin)
- Removed from U.S. market in 2006 due to fatalities (Hypoglycemia related)
- Hypoglycemia with Gatifloxacin (Tequin)
- Has occurred in non-diabetics
- Contraindicated in Diabetes Mellitus
- See Fluoroquinolone