• See Also
  1. Pinworm
  • Indications
  1. Pinworm
  2. Roundworm
  3. Hookworm (off-label)
  • Mechanism
  1. Depolarizing Neuromuscular Blocking Agent active in Helminths (worms)
    1. Results in persistent Nicotinic Receptor (Acetylcholine) activation
    2. Leads to spastic paralysis of nematodes (e.g. Pinworms, roundworms, Hookworms)
  • Medications
  1. Pyrantel Pamoate 144 mg/ml suspension (Pin-X): Contains 50 mg/ml of Pyrantel base
  2. Pyrantel Pamoate 720 mg Tablets: Contains 250 mg of Pyrantel base
  3. Pyrantel Pamoate 180 mg Tablets: Contains 62.5 mg of Pyrantel base
  • Dosing
  • Adults and Children
  1. Pinworms
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally for one dose now and again in 2 weeks
  2. Roundworms
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally for one dose
  3. Hookworms (off-label)
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally daily for 3 days
  • Pharmacokinetics
  1. Not absorbed
  • Safety
  1. Not absorbed
  2. Pregnancy Category C
  3. Unknown safety in Lactation
  • Resources
  1. Pyrantel Pamoate Suspension (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e862b337-2991-4b56-8584-fd80dccd725f
  2. Pyrantel Pamoate Tablet
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e68dd24a-93f8-4e2e-a698-d9ad9a7cebac