Pharm

Peginterferon Alfa-2A

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Peginterferon Alfa-2A, Pegylated Interferon Alfa-2A, Pegasys

  • See Also
  1. Interferon Alfa-2B
  • Indications
  1. Chronic Hepatitis B Infection
  2. Hepatitis C Infection
    1. See Hepatitis C Treatment with Interferon and Ribavirin
    2. Replaced by other Hepatitis C Antiviral Regimens, with the exception of a few Genotypes
  • Contraindications
  1. Decompensated Cirrhosis (Child-Pugh Class >=6)
  2. Autoimmune Hepatitis
  • Mechanism
  1. See Interferon Alfa-2B
  2. Pegylated Interferon is recombinant Interferon alfa conjugated to Polyethylene Glycol (PEG)
    1. PEG component decreases Interferon clearance and extends its therapeutic effects
    2. Pegylated Interferon is typically preferred over the non-pegylated Interferon (e.g. Interferon Alfa-2B)
  1. Store in refrigerator
  2. Adult
    1. Dose 180 mg SQ in Abdomen or thigh once weekly for 48 weeks
  3. Renal: Decrease dose if eGFR <30 ml/min or Hemodialysis
    1. Dose 135 mcg SQ weekly
  • Adverse Effects
  1. See Interferon Alfa-2B
  • Safety
  1. Pregnancy Category C
  2. Avoid in Lactation
  • Monitoring
  1. See Interferon Alfa-2B
  • Resources
  1. Peginterferon Alfa-2A (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=de61685e-2b8c-4e22-84bb-869e13600440
  • References
  1. (2013) Med Lett Drugs Ther 11(127): 19-30 [PubMed]