• Indications
  1. Onchocerciasis (age 12 years and older)
  • Mechanism
  1. Avermectin Antiparasitic and antihelminth agent similar to Ivermectin
  2. Greater use in veterinary rather than human medicine (beyond its indication for Onchocerciasis)
  • Medications
  1. Tablets: 2 mg
  • Dosing
  • Adults (and Children age >12 years old)
  1. Take 8 mg (four tablets) orally for one dose
    1. Drug levels persist for months after dose
  • Pharmacokinetics
  1. Half-Life: 23 days
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Adverse Effects
  • General
  1. Orthostatic Hypotension
  2. Encephalopathy
    1. Occurs with coinfection with Loa loa
    2. Evaluate for Loa loa prior to treatment
  3. Onchodermatitis exacerbation
    1. Associated with hyperreactive Onchodermatitis (Sowda)
  • Adverse Effects
  • Mazzotti Reaction (Immunologic Reaction in Onchocerciasis to Parasite Death)
  1. Nausea
  2. Fever
  3. Headache
  4. Arthralgias
  5. Urticaria
  6. Ophthalmic complications
  • Resources
  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. Moxidectin Tablets (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6eb02ae9-9065-176f-e053-2991aa0ac891