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Imipenem-Cilastin Relebactam

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Imipenem-Cilastin Relebactam, Recarbio

  • See Also
  1. Imipenem Cilastin
  2. Carbapenem
  • Indications
  1. See Carbapenem
  2. Indicated in complicated UTI or intra-abdominal infections where other options have been exhausted
  • Mechanism
  1. See Carbapenem
  2. Recarbio is a combination of Imipenem-Cilastin with Relebactam
  • Dosing
  • Adults
  1. CrCl >=90 ml/min
    1. Give 1.25 g IV every 6 hours administered over 30 minutes
  2. CrCl 60 to 89 ml/min
    1. Give 1 g IV every 6 hours administered over 30 minutes
  3. CrCl 30 to 59 ml/min
    1. Give 0.75 g IV every 6 hours administered over 30 minutes
  4. CrCl 15 to 29 ml/min
    1. Give 0.5 g IV every 6 hours administered over 30 minutes
  5. CrCl <15 ml/min
    1. Avoid unless Hemodialysis planned for within 48 hours
    2. Administer after Hemodialysis
  • Drug Interactions
  1. See Carbapenem
  • Adverse Effects
  1. See Carbapenem
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Resources
  1. Imipenem-Cilastin Relebactam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=be32f468-738b-40df-a425-591e12f65159
  • References
  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]