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Ertapenem

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Ertapenem, Invanz

  • See Also
  1. Carbapenem
  • Indications
  1. See Carbapenem
  2. Avoid in Pseudomonas and Acinetobacter infections (inactive)
  3. Complicated Infections
    1. Community Acquired Pneumonia (limited activity)
    2. Diabetic Foot Infections
    3. Acute Intraabdominal and Pelvis Infections
    4. Complicated Skin and Soft Tissue Infections
    5. Complicated Urinary Tract Infections
  • Mechanism
  1. See Carbapenem
  • Dosing
  1. Administration
    1. Administer IV doses over 30 minutes (and do not combine with dextrose solutions)
    2. Dilute IM doses with Lidocaine (if not allergic)
    3. FDA approved duration up to 14 days IV and up to 7 days IM
  2. Adult (and age >12 years)
    1. Standard Dose: 1 g IM/IV every 24 hours (or 1 hour prior to surgical incision)
    2. Renal Dosing
      1. CrCl <30 ml/min: 500 mg IV every 24 hours
      2. Hemodialysis: 500 mg IV every 24 hours
        1. Give additional 150 mg after Dialysis if dose within 6 hours prior to Dialysis
    3. Child (3 months to 12 years)
      1. Dose: 15 mg/kg IV or IM every 12 hours (max total daily dose: 1 gram/day)
  • Drug Interactions
  1. See Carbapenem
  • Adverse Effects
  1. See Carbapenem
  • Safety
  1. Unknown safety in pregnancy
  2. Safe in Lactation
  • Resources
  1. Ertapenem (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=33f3b99b-fa82-42e0-26bf-f49891ae3d22
  • References
  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]