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Doripenem

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Doripenem, Doribax

  • See Also
  1. Carbapenem
  • Indications
  1. See Carbapenem
  2. Primarily used in severe aerobic Gram-Negative Bacterial infections
    1. Complicated Urinary Tract Infections including Pyelonephritis
    2. Complicated intraabdominal infections
  3. Avoid in Bacterial Pneumonia (increased mortality)
  4. Doripenem may have greater Pseudomonas activity than other Carbapenems
    1. Otherwise similar spectrum of activity as Imipenem Cilastin and Meropenem
  • Mechanism
  1. See Carbapenem
  • Dosing
  1. Adult Dosing
    1. Give 500 mg IV every 8 hours for 5 to 14 days
  2. Renal Dosing
    1. CrCl 30-50 ml/min: 250 mg IV every 8 hours
    2. CrCl 10-30 ml/min: 250 mg IV every 12 hours
  • Drug Interactions
  1. See Carbapenem
  • Adverse Effects
  1. See Carbapenem
  • Safety
  1. Pregnancy Category B
  2. Unknown safety in Lactation
  • Resources
  1. Doripenem (DailyMed)
    1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022106s008lbl.pdf
  • References
  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]