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Neutropenic Fever Clinical Decision Rule

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Neutropenic Fever Clinical Decision Rule, Multinational Association for Supportive Care in Cancer Risk Index, MASCC Risk Index

  • See Also
  1. Neutropenic Fever
  2. Neutropenia
  3. CISNE Score
  • Indications
  1. Assess risk in Neutropenic Fever
  • Contraindications
  1. Children under age 16 years (have different rules for risk stratification)
  • Criteria
  1. Neutropenic Fever symptom severity (choose one)
    1. No symptoms or Mild symptoms: 5 points
    2. Moderate symptoms: 3 points
  2. Hypotension not present: 5 points
  3. COPD not present: 4 points
  4. Solid tumor or non-fungal infection: 4 points
  5. Dehydration not present: 3 points
  6. Fever had onset as outpatient: 3 points
  7. Age under 60 years: 2 points
  • Interpretation
  1. Total score >21: Low Risk (consider outpatient therapy)
  2. Total score <21: High Risk (inpatient therapy)
  • References
  1. Hughes (2002) Clin Infect Dis 34:730-51 [PubMed]
  2. Klastersky (2000) J Clin Oncology 18(16): 3038-51 [PubMed]
  3. Talcott (1992) J Clin Oncol 10:316-22 [PubMed]