Pharm

Tirofiban

search

Tirofiban, Aggrastat

  • See Also
  1. Glycoprotein IIB/IIIA Inhibitor
  2. Abciximab
  3. Eptifibatide
  • Indications
  1. Non-ST elevation Myocardial Infarction (NSTEMI)
  • Contraindications
  1. Recent major bleeding
  • Mechanism
  1. Inhibits Platelet aggregation via Glycoprotein IIb/IIIa receptors on Platelet plasma membranes
  2. Inhibits Fibrinogen binding to Platelets
  • Dosing
  1. Non-ST elevation Myocardial Infarction (NSTEMI)
    1. Load: 25 mcg/kg over 5 min
    2. Infuse: 0.15 mcg/kg/min for up to 18 hours
      1. Slow rate to 0.075 mcg/kg/min if GFR <=60 ml/min
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Resources
  1. Tirofiban (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fe0ced75-ccbf-4d2e-bd0d-b57e60ab913f