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Floxuridine

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Floxuridine, FUDR, Fluorodeoxyuridine

  • See Also
  1. Antimetabolite Chemotherapy
  2. Chemotherapy
  • Indications
  1. Colorectal Liver Metastases (Palliative Care)
  • Mechanism
  1. Fluorinated Pyrimidine Antimetabolite Chemotherapy with antineoplastic activity
  2. Analog of FUDR-MP
    1. Inhibits thymidylate synthase, blocking DNA synthesis
  3. Also metabolized to Fluorouracil
    1. As a uracil analog, Fluorouracil inhibits RNA synthesis
  • Medications
  1. Floxuridine IV Solution
    1. Available in 0.5 g vials of lyophilized powder for reconstitution
  • Dosing
  1. See other references for disease specific dosing protocols
  2. Colorectal Liver Metastases
    1. Administered by infusion pump via intrahepatic artery
  • Adverse Effects
  1. Myelosuppression
  2. Nephrotoxicity
  3. Hepatotoxicity
  4. Alopecia
  • Safety
  1. Avoid in Lactation
  2. Avoid in pregnancy (all trimesters)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count
    2. Liver Function Tests
    3. Renal Function tests
  • Resources
  1. Floxuridine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c8edabc1-67cd-421b-a147-7c1f19f05b8e