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Fibrinogen Concentrate

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Fibrinogen Concentrate

  • See Also
  1. Cryoprecipitate
  2. Fresh Frozen Plasma
  3. Hemorrhagic Shock
  • Indications
  1. Massive Hemorrhage (e.g. Trauma, cardiac surgery, Postpartum Hemorrhage)
    1. Alternative to Cryoprecipitate
    2. Trauma or Gastrointestinal Bleeding
      1. Transfuse Fibrinogen Concentrate (or Cryoprecipitate) if Fibrinogen <150 mg/dl
    3. Postpartum Hemorrhage
      1. Transfuse Fibrinogen Concentrate (or Cryoprecipitate) if Fibrinogen <200 mg/dl
  1. Noninferior to cryprecipitate in cardiac surgery related bleeding
    1. Farkouh (2019) JAMA 322(20): 1966-76 [PubMed]
  2. In contrast to Cryoprecipitate, Fibrinogen has several advantages
    1. Consistent dosing (variable with Cryoprecipitate)
    2. Rapidly reconstituted (no thawing needed)
    3. Longer shelf life (24 hours instead of 6 hours)
    4. No major transfusion adverse effects
  • References
  1. Petrosoniak and Swaminathan in Swadron (January, 2023) EM:RAP