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Edoxaban

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Edoxaban, Savaysa

  • See Also
  1. Direct Oral Anticoagulant
  2. Anticoagulation
  3. Apixaban
  4. Rivaroxaban
  5. Fondaprinux
  6. Dabigatran
  7. Heparin
  8. Warfarin
  • Mechanism
  1. Factor Xa Inhibitor
  • Indications
  1. Atrial Fibrillation Anticoagulation
  2. Deep Vein Thrombosis
    1. However, must be started concurrently with Heparin, unlike other Factor Xa Inhibitors (Apixaban, Rivaroxaban)
  • Contraindications
  1. Creatinine Clearance <15 ml/min/1.73m2
  2. Creatinine Clearance >95 ml/min/1.73m2 (lower efficacy due to high drug clearance)
  3. Severe Cirrhosis (Child-Pugh Class C)
  • Dosing
  1. Standard dose: 60 mg orally daily
  2. Half dose indications (30 mg orally daily)
    1. Creatinine Clearance 15 to 50 ml/min/1.73m2 OR
    2. Weight <60 kg
  • Pharmacokinetics
  1. Oral Bioavailability: 62%
  2. Half-Life: 10-14 hours
  3. Onset: 1-2 hours
  4. Renal Clearance 50%
  • Drug Interactions
  1. Inducers
    1. Avoid Rifampin
  2. P-Glycoprotein Inhibitors
    1. Clarithromycin
    2. Dronedarone
    3. Itraconazole
    4. Ketoconazole
    5. Verapamil
  • Safety
  1. Unknown Safety in Pregnancy
  2. Unknown Safety in Lactation
  • Resources
  1. Edoxaban (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e77d3400-56ad-11e3-949a-0800200c9a66
  • References
  1. Steinberg (2014) BMJ 348: g2116 +PMID:24733535 [PubMed]
  2. Wilbur (2017) Am Fam Physician 95(5): 295-302 [PubMed]