- Atrial Fibrillation Anticoagulation
-
Deep Vein Thrombosis
- However, must be started concurrently with Heparin, unlike other Factor Xa Inhibitors (Apixaban, Rivaroxaban)
- Creatinine Clearance <15 ml/min/1.73m2
- Creatinine Clearance >95 ml/min/1.73m2 (lower efficacy due to high drug clearance)
- Severe Cirrhosis (Child-Pugh Class C)
- Standard dose: 60 mg orally daily
- Half dose indications (30 mg orally daily)
- Creatinine Clearance 15 to 50 ml/min/1.73m2 OR
- Weight <60 kg
- Oral Bioavailability: 62%
- Half-Life: 10-14 hours
- Onset: 1-2 hours
- Renal Clearance 50%
- Unknown Safety in Pregnancy
- Unknown Safety in Lactation