Atrazanavir, Reyataz, ATV

  • Mechanism
  • Adverse Effects
  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Indirect Hyperbilirubinemia
  3. Rash (20%)
    1. Does not typically require stopping the medication
  4. Nephrolithiasis
  5. EKG Abnormalities
    1. PR prolongation
    2. Other cardiac conduction abnormalities
  • Dosing
  1. Take with food
  • Drug Interactions
  1. Acid suppressants (Proton Pump Inhibitors, H2 Blockers)
    1. Proton Pump Inhibitors renders Atrazanavir ineffective and results in a high risk of developing resistance
    2. Atrazanavir requires acid in Stomache for absorption