Pharm

Atrazanavir

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Atrazanavir, Reyataz, ATV

  • See Also
  1. Anti-Retroviral Therapy
  2. Protease Inhibitor
  • Mechanism
  1. Protease Inhibitor
  • Adverse Effects
  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Indirect Hyperbilirubinemia
  3. Rash (20%)
    1. Does not typically require stopping the medication
  4. Nephrolithiasis
  5. EKG Abnormalities
    1. PR prolongation
    2. Other cardiac conduction abnormalities
  • Dosing
  1. Take with food
  • Drug Interactions
  1. Acid suppressants (Proton Pump Inhibitors, H2 Blockers)
    1. Proton Pump Inhibitors renders Atrazanavir ineffective and results in a high risk of developing resistance
    2. Atrazanavir requires acid in Stomache for absorption
  • References
  1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  2. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]