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Ophthalmic Cyclosporine

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Ophthalmic Cyclosporine, Ophthalmic Calcineurin Inhibitor, Restasis, Cyclosporine Ophthalmic Emulsion, Cyclosporine Ophthalmic Suspension

  • See Also
  1. Keratoconjunctivitis Sicca (Sjogren's Syndrome)
  2. Ophthalmic Corticosteroid
  3. Ocular Nonsteroidal Antiinflammatory Drug
  • Indications
  1. Keratoconjunctivitis Sicca (Sjogren's Syndrome)
  • Mechanism
  1. Cyclosporine is a Calcineurin Inhibitor with Immunosuppression and antiinflammatory properties (esp. inhibits T-Helper Cells)
  2. Improves tear production in autoimmune disorders (esp. Sjogren's Syndrome)
  • Medications
  1. Restasis 0.05% emulsion (preferred as generic option, $200/month)
  2. Other non-generic options (at $500-$800 per month)
    1. Cequa 0.09% solution
    2. Veyve 0.1% solution
  • Dosing
  1. Use 1 drop in each eye every 12 hours
  2. Remove contacts before instilling drops (and wait 15 min before reinserting)
  3. Separate from other ophthalmic topicals by at least 15 minutes
  • References
  1. (2025) Presc Insights 32(11): 66