- Toxic Multinodular Goiter is second most common cause of Hyperthyroidism in U.S. (5% of cases)
- Diets deficient in Iodine (esp. elderly)
- Simple Goiter develops into Multinodular Goiter
- Non-Toxic Multinodular Goiter
- Toxic Multinodular Goiter (50%)
- Increase in clonogenic cells with TSH receptor mutation (somatic activating)
- Results in Thyrotoxicosis
- Toxic Multinodular Goiter (Thyrotoxicosis)
- Cardiovascular complications
- No Ophthalmopathy (Proptosis and stare)
- No Dermopathy
- Both Toxic and Non-Toxic Multinodular Goiter
- Superior Vena Cava Syndrome
- Results from thoracic outlet obstruction
- Superior Vena Cava Syndrome