Pharm
Tolnaftate
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Tolnaftate
, Tinactin
See Also
Topical Antifungal
Indications
Superficial dermatophyte infections (e.g.
Tinea Pedis
,
Tinea Cruris
,
Tinea Corporis
)
Other
Topical Antifungal
s are preferred (primarily fungistatic rather than fungicidal)
Mechanism
Naphthalene (2 ring
Hydrocarbon
extracted from coal tar) and Thiocarbamate derivative
Primarily fungistatic (as opposed to fungicidal), leaving it less effective at resolution than other
Antifungal
s
Other
Topical Antifungal
s are preferred
Selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase
Inhibits ergosterol synthesis, a key component in fungal cell walls
Also impairs mycelial growth and results in distorted hyphae
Medications
Tolnaftate 1% available OTC in U.S. in creams, solutions, powders, gels and sprays
Dosing
Superficial dermatophyte infections (e.g.
Tinea Pedis
,
Tinea Cruris
,
Tinea Corporis
)
Apply twice daily
Safety
Unknown safety in pregnancy
Unknown safety in
Lactation
Resources
Tolnaftate Cream (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c3b715a9-233a-401a-ba60-f78c1ddf1ded
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