Pharm

Econazole

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Econazole, Ecoza, Spectazole

  • See Also
  1. Topical Antifungal
  • Indications
  1. Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
  2. Cutaneous Candidiasis
  • Contraindications
  1. Not FDA approved in children
  • Mechanism
  1. Imidazole Antifungal
  2. As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
    1. Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)
  3. Other activity specific to Econazole
    1. Endogenous respiration inhibitor
    2. Purine uptake inhibitor
    3. Phospholipid synthesis inhibitor
  • Medications
  1. Cream: 1%
  2. Foam: 1%
  • Dosing
  • Superficial dermatophyte infections and Candidiasis
  1. Apply once daily for dermatophyte infections for 2 weeks (4 weeks for Tinea Pedis)
  2. Apply twice daily for Cutaneous Candidiasis for 2 weeks
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Drug Interactions
  1. Unlikely Drug Interactions given minimal absorption
  2. Warfarin
    1. May increase INR
  • Resources
  1. Econazole Cream (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51fd5746-8313-4f68-b929-8481ad8ca241
  2. Econazole Foam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=998798bc-5c64-4e4c-a0d6-925278ff76a4