Pharm

Calcipotriene

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Calcipotriene, Donovex

  • Indication
  1. Psoriasis
  • Dosing
  1. Ointment applied qd-bid
  • Efficacy
  1. Begin to see benefit in 2 weeks
  2. Maximum benefit in 6-8 weeks
    1. Resolution in 10% of patients
    2. Moderate Improvement in 70% of patients
    3. No Improvement in 20% of patients
  3. Useful adjunct to PUVA
  • Adverse effects
  1. May be irritating, more so in fold areas
  2. Do not use on face
  3. Vitamin D analog - risk of Hypercalcemia
    1. Limit to 100 grams per week
  • Disadvantages
  1. Expensive ($100 for 2 ounces)