Fungus

Majocchi Granuloma

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Majocchi Granuloma, Majocchi's Granuloma

  • See Also
  1. Tinea Corporis
  • Epidemiology
  1. Rare
  • Pathophysiology
  1. Dermatophyte Infection (esp. Trichophyton rubrum)
  2. Complication of Corticosteroid use for Tinea Corporis
  3. Deep Fungal Infection extending to the Dermis
    1. Contrast with Tinea Corporis which is limited to the superficial skin
  • Risk Factors
  1. Tinea Infection
  2. Extremity Trauma
  3. Topical Corticosteroid use
  • Findings
  1. Pruritic, warm, pink-Red Papules, Nodules and Plaques on the extremities
  • Diagnosis
  1. Diagnosis is typically delayed 1-2 months
  2. Skin biopsy
    1. Perifollicular Granulomatous inflammation
  3. Microbial testing does not differentiate deep (Majocchi Granuloma) from superficial (e.g. Tinea Corporis)
    1. Potassium Hydroxide (KOH Preparation)
    2. Fungal Culture
  • Management
  1. Variable protocols for 1 month or more
    1. Oral Terbinafine AND
    2. Topical Ketoconazole
  • References
  1. Ballas (2025) Am Fam Physician 112(5): 561-2 [PubMed]
  2. Khodadadi (2023) JAAD Int 13:104-11 +PMID: 37744668 [PubMed]
  3. Boral (2018) Infect Drug Resist 11:751-60 +PMID: 29861637 [PubMed]